A bacteria discovered on Easter Island may hold the key to the proverbial fountain of youth by producing rapamycin, which inhibits the engine-of-aging enzyme TOR.
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References
R Zoncu, A Efeyan, D M Sabatini. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011 12(1):21 – 35.
M V Blagosklonny. Aging is not programmed: genetic pseudo-program is a shadow of developmental growth. Cell Cycle. 2013 12(24):1–7.
S C Johnson, P S Rabinovitch, M Kaeberlein. mTOR is a key modulator of ageing and age-related disease. Nature. 2013 493(7432):338 – 345.
M V Blagosklonny. Why human lifespan is rapidly increasing: Solving longevity riddle with revealed-slow-aging hypothesis. Aging (Albany NY). 2010 2(4):177 – 182.
M V Blagosklonny. TOR-driven aging: Speeding car without brakes. Cell Cycle. 2009 8(24):4055 – 4059.
L Fontana, T E Meyer, S Klein, J O Holloszy. Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk. Rejuvenation Res 2007. 10(2):225 – 234.
B A Dar, M A Dar, S. Bashir. Calorie Restriction the Fountain of Youth. Food Nutr Sci. 2012 3(11):1522 – 1526.
R Pallavi, M Giorgio, P G Pelicci. Insights into the beneficial effect of caloric/ dietary restriction for a healthy and prolonged life. Front Physiol. 2012 3:318.
A J Dirks, C Leeuwenburgh. Caloric restriction in humans: potential pitfalls and health concerns. Mech Ageing Dev. 2006 127(1):1 – 7.
C Vézina, A Kudelski, SN Sehgal. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo). 1975 28(10):721 – 726.
